教育背景
Medicine Postdoctoral Fellow - 2014 Northwestern University, Institute for BioNanotechnology
神经科学Ph值.D - 2009 Indian Institute of Technology (in collaboration with Brain Science Institute, RIKEN, Japan)
Medical Science and Technology M.S - 2004 Indian Institute of Technology
M.B.B.S. - 2000 University of Calcutta
课程
- BY471 - Anatomy and Physiology I
- BY473 - Anatomy and Physiology I Laboratory
研究兴趣
The biochemical and biophysical properties of cellular microenvironment send instructive signals to cells to control a variety of processes such as proliferation, 迁移, differentiation and apoptosis. Our lab aims for a molecular level understanding of these regulatory mechanisms using designed artificial matrices as a tool. In collaboration with experts from the field of chemistry and materials science, the matrices will be built on a modular, self-assembled materials platform to take advantage of the controllable nanostructure and mechanical properties these materials afford. 除了, such materials have the ability to present or release of bioactive molecules and incorporate dynamic properties such as stimuli-triggered spatio-temporal modulation in the material properties and bioactivity. We will focus on understanding how material properties such as stiffness, 地形, alignment and surface charge affect the events at the cell-material interface (e.g. receptor mobility and clustering, cytoskeletal organization) and how these surface interactions lead to activation of signaling cascades and modulation of gene expression. We will also investigate the significance of temporal presentation of extracellular cues on cell development. Our long-term goal is to improve stem cell-based regenerative strategies where rationally designed materials could be used to drive transplanted cells into preferred cell lineage and function.
出版物
出版物 (last 5 years)
* indicates equally contributing authors
- Saahir汗 纳拉苏尔, Patricia Dankers, Ricardo Da Silva, Job Boekhoven, Taylor Poor塞缪尔一世. 粗汞华 (2014): “Post-assembly functionalization of supramolecular nanostructures with bioactive peptides and fluorescent proteins by native chemical ligation”, Bioconjugate Chemistry, Volume 25, Issue 4, 707-717.
- 纳拉苏尔穆斯塔法O. 马修·J·居勒.尤金·T·韦伯. Pashuck, Masao Ito塞缪尔一世. 粗汞华, Thomas Launey (2014): “Synergistic regulation of cerebellar Purkinje neuron development by laminin epitopes and collagen on an artificial hybrid matrix construct”, 生物材料科学, Volume 2, Issue 6, 903-914
- 克里斯蒂娜J. 纽科姆*, 纳拉苏尔*，朱莉娅·H. Ortony, One-Sun Lee, John B. Matson, Job Boekhoven, Jeong Min Yu, George C. 沙茨，塞缪尔一世. 粗汞华 (2014): “Cell death versus cell survival instructed by supramolecular cohesion of nanostructures”, 自然通讯，卷5,3321.
- 埃里克J. Berns *, 纳拉苏尔*，乔舒亚E. 《塞缪尔·戈德伯格. 粗汞华 (2014): “Aligned neurite outgrowth and directed 迁移 in monodomain gels of self-assembling, peptide based nanofibers”, 生物材料, Volume 35, Issue 1, 185-195.
- Job Boekhoven, Charles Perez Rubert, 纳拉苏尔, Amanda Worthy塞缪尔一世. 粗汞华 (2013): “Dynamic display of bioactivity via host guest chemistry”, Angewandte Chemie Int Ed English, Volume 52, Issue 46, 12077-12080.
- 纳拉苏尔*，克里斯蒂娜·J. 马修·J·纽科姆*. 韦伯，塞缪尔一世. 粗汞华 (2013): “Tuning supramolecular mechanics to guide neuron development”, 生物材料, Volume 34, Issue 20, 4749-4757.
- R. 海伦咋, 纳拉苏尔塞缪尔一世. 粗汞华 (2013): “Self assembly of cytotoxic peptide amphiphiles into supramolecular membranes for cancer therapy”, Advanced 健康care Materials, Volume 2, Issue 1, 126-133.
- Sungsoo年代. 布莱恩·李. 黄，斯图尔特R. Kaltz, 纳拉苏尔克里斯蒂娜·J. 斯图尔特·纽科姆. Ramille N .斯托克. 沙阿，塞缪尔一世. 粗汞华 (2013): “Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds”, 生物材料, Volume 34, Issue 2, 452-459.
- 纳拉苏尔*、约翰·B. 马修·马特森*.克里斯蒂娜·韦伯. 塞缪尔·纽科姆. 粗汞华 (2012): “Photodynamic control of bioactivity in a self-assembled matrix,” ACS Nano, Volume 6, Issue 12, 10776-10785.
- Saahir汗 纳拉苏尔克里斯蒂娜·J. 伊丽莎白·纽科姆. 撒母耳一世. 粗汞华 (2012): “Self-Assembling glucagon-like peptide 1-mimetic peptide amphiphiles for enhanced activity and proliferation of insulin-secreting cells”, Acta Biomaterialia, Volume 8, Issue 5, 1685-1692.
- 纳拉苏尔, Eugene Pashuck, Mustafa Guler, Masao Ito塞缪尔一世. 粗汞华, Thomas Launey (2012): “A hybrid nanofiber matrix to control the survival and maturation of brain neurons” 生物材料, Volume 33, Issue 2, 545-555.